May 16, 2022

Ocrevus VS Tysabri in Treating Multiple Sclerosis

Specialty Infusion Blog Jess

Ocrevus (ocrelizumab)

Ocrevus, which is the generic name for the pharmaceutical drug, Ocrelizumab, is prescribed to treat relapsing types of multiple sclerosis (MS), such as clinically isolated syndrome, illness, and active secondary progressive disease in individuals with primary progressive MS. 

Ocrevus uses a therapeutic monoclonal antibody that takes a novel approach to treat multiple sclerosis. It targets CD20-positive B cells, a type of immune cell that plays a critical role in the disease. The FDA has approved Ocrevus to treat relapsing or primary progressive multiple sclerosis (MS). Ocrevus is administered as an intravenous (IV) infusion once every six months.

Who can take Ocrevus?

Individuals with active relapsing-remitting MS and highly active relapsing-remitting MS who are unable to take Lemtrada may be given Ocrevus.

Contraindications of Ocrevus:

Consult your doctor about any current medications you are taking or underlying illnesses you already have to ensure that this drug will be right for you. If you have severe illnesses such as cancer or serious infections like HIV/AIDS or hepatitis B, you may not be a good candidate for the medication.

Conception and pregnancy:

While you are being treated with Ocrevus, it is advised to abstain from pregnancy. If you are planning for a baby, consult your health care provider for advice concerning your personal situation. During treatment and for 12 months after stopping Ocrevus, women of childbearing age must use a form of contraception.

Administration and Dosage of Ocrevus:

Ocrevus is administered as a biweekly intravenous infusion for two doses, followed by a maintenance dosage for  six months.

Common Side Effects of Ocrevus:

Infections and reactions to infusions are common side effects of Ocrevus. 

Tysabri (Natalizumab)

Tysabri, the generic brand name for the pharmaceutical drug natalizumab is a medication used to treat patients with relapsing forms of MS. It can reduce the frequency of flare-ups and help prevent physical limitations as a result of the disease from rapidly worsening.

The mechanism of Tysbari is different from other multiple sclerosis medications. It prevents white blood cells in the immune system from accessing the brain and spinal cord, which scientists believe plays a key part in the progression of MS’s debilitating symptoms.

The FDA has approved Tysabri as a monotherapy (not to be used in conjunction with other disease-modifying medicines) for the treatment of relapsing types of multiple sclerosis, such as clinically isolated syndrome, relapsing-remitting disease (RRMS), and active secondary progressive disease (ASPD) (SPMS with relapses). 

Administration and Dosage:

Tysabri is administered every four weeks through intravenous infusions.

Common Side Effects:

Adverse side effects of Tysabri include liver dysfunction, allergic reactions, a compromised immune system and low platelet counts. Tysabri may also cause complications if you have certain forms of herpes, leading to severe and possibly fatal, herpes infections. Call your doctor right away if you experience any herpes infections. 

Other side effects of the drug include headache, fatigue, urinary tract infections, joint pain, lung infections, depression, pain in the arms or legs, diarrhea, and vaginitis. Rash, nose and throat infections, nausea, and stomach discomfort are all symptoms of a urinary tract infection. Consult your healthcare provider if any side effects you experience worsen in severity or persist for a long period of time. 

Difference between Ocrevus Vs Tysabri

Monoclonal antibodies such as Ocrevus (ocrelizumab) injection and Tysabri (natalizumab) are used to treat relapse types of multiple sclerosis (MS).

Ocrevus is also used to treat primary progressive multiple sclerosis (MS).

In adults, Tysabri is prescribed to treat moderate to severe Crohn’s disease. Tysabri is frequently used when previous Crohn’s disease drugs have failed to treat the illness effectively. Monoclonal antibodies like Ocrevus and Tysabri are two different kinds. Tysabri is a recombinant humanised IgG4, a monoclonal antibody, and Ocrevus, a CD20-directed cytolytic antibody.

Depression is a common side effect of both Ocrevus and Tysabri. Infections like upper and lower respiratory tract infections, infusion reactions (such as itching, rash, hives, redness, bronchospasm, throat irritation and swelling, mouth pain, shortness of breath, flushing, hypotension, fever, fatigue, headache, dizziness, nausea, and fast heart rate), skin problems, backache, and pain in the legs and feet are all side effects of Ocrevus that do not occur with Tysabri.

Headache, tiredness, joint or muscle pain, redness or irritation at the injection site, swelling hands/feet/ankles, changes in the menstrual cycle, painful menstrual cramps, stomach pain, diarrhea, skin rash, and cold symptoms such as stuffy nose, sneezing, or sore throat are all side effects of Tysabri.

Both Ocrevus and Tysabri have the potential to interact with other immune-modulating or immunosuppressive medicines, such as immunosuppressive corticosteroids, chemotherapy, or radiation.

What drugs interact with Ocrevus?

Interaction of Ocrevus can occur when it is taken in combination with other immunosuppressive agents and immune-modulating therapies such as immunosuppressant doses of corticosteroids. It is essential to consult your doctor about all the supplements and medications you are currently using to prevent any drug complications, 

What drugs interact with Tysabri?

Interactions of Tysabri can occur when it is taken in combination with  medicines that may affect the immune system like sirolimus, interferon cyclosporine, azathioprine, tacrolimus, mofetil, muromonab-CD3, leflunomide, basiliximab, etanercept, radiation treatment and chemotherapy.

How should Ocrevus be taken?

Before starting Ocrevus, you must undergo a hepatitis B virus test. Before each infusion, take methylprednisolone (or a comparable corticosteroid) and an antihistamine. The initial dose of Ocrevus is a 300 mg intravenous infusion, followed by a second 300 mg intravenous infusion two weeks later, and a 600 mg intravenous infusion every six months after that. 

How should Tysabri be taken?

300mg is the suggested dose of Tysabri for Crohn’s disease and multiple sclerosis through intravenous infusion over one hour every four weeks.